Modern Approaches to the Diagnosis of Cognitive Impairment and Alzheimer’s Disease: A Narrative Literature Review

BACKGROUND: The aging of the worlds population leads to an increase in prevalence age-related diseases, including cognitive impairment. At stage dementia, therapeutic interventions become usually ineffective. Therefore, researchers and clinical practitioners today are looking for methods that allow early diagnosis impairment, techniques based on use biological markers.
 AIM: aim this literature review is delve into scientific papers centered modern laboratory tests Alzheimers disease, markers at stages impairment.
 METHODS: authors have carried out a descriptive published from 2015 2023. Studies included PubMed Web Science electronic databases were analyzed. A analysis was used summarized gleaned information.
 RESULTS: Blood cerebrospinal fluid (CSF) biomarkers, as well advantages disadvantages their use, reviewed. most promising neurotrophic, neuroinflammatory, genetic markers, polygenic risk models, also discussed.
 CONCLUSION: biomarkers practice will contribute impairment associated with disease. Genetic screening can improve detection threshold preclinical abnormalities absence obvious symptoms decline. active practice, combination timeliness effectiveness medical interventions.